Treatment outcomes of corpus uteri cancer at Moi Teaching and Referral Hospital, Kenya: A 10-year retrospective study

Authors

  • Dr. Faiza Nassir Department of Reproductive Health,College of Health Sciences,Moi University School of Medicine, Eldoret, Kenya.
  • Dr. Peter Itsura Department of Reproductive Health, Moi University, Eldoret, Kenya
  • Dr. Benjamin Elly Odongo Department of Reproductive Health, Kenyatta University, Nairobi, Kenya
  • Prof. Elkanah Omenge Orang'o Department of Obstetrics and Gynecology, Aga Khan University, Nairobi, Kenya
  • Dr. Philliph K. Tonui Department of Reproductive Health, Moi University, Eldoret, Kenya
  • Dr. Henry Chege Department of Obstetrics and Gynecology, Nyeri Teaching and Referral Hospital, Nyeri, Kenya
  • Dr. Anisa W.Mburu Department of Obstetrics and Gynecology, Aga Khan Hospital, Mombasa, Kenya
  • Hellen N. Muliro Academic Model Providing Access to Healthcare (AMPATH) Kenya - Moi University, Eldoret, Kenya
  • Dr. Barry P. Rosen Division of Gynecologic Oncology, University of Toronto, Sunnybrook Health Science Centre, Toronto, Canada
  • Dr. Allan L. Covens Department of Gynecology Oncology, Beaumont Hospital, Royal Oak, Michigan, United States

DOI:

https://doi.org/10.59692/jogeca.v35i3.56

Keywords:

adjuvant therapy, , corpus uteri cancer, endometrial carcinoma, histology

Abstract

Background: Corpus uteri cancer is the sixth most common cancer worldwide, with 417 000 new cases diagnosed annually. It has a wide variation in incidence, with the highest and lowest rates reported in North America and Africa, respectively.

Objective: To describe the clinicopathological and treatment outcomes of corpus uteri cancer at Moi Teaching and Referral Hospital (MTRH) in Eldoret, Kenya.

Methods: A retrospective descriptive review of the database of all corpus uteri cancer patients seen at MTRH between 2011 and 2021 was conducted. Data were entered and analyzed using the Statistical Package for Social Sciences (SPSS), version 24. Descriptive and inferential statistics were performed, and the results were presented in tables and figures. Statistical significance was set at p<0.05.

Results: 95 files were included in this study. The mean age of the participants was 62 years. Most participants, 88 (92.6%)  and 61 (64.3%) were postmenopausal and multiparous, respectively. Endometrial cancer and uterine sarcoma accounted for 72% and 23% of all cases, respectively. Endometrioid and carcinosarcoma were the most common histological types in each group. Recurrence mostly occurred within the first two years after treatment and was mainly locoregional in 75% of cases. Adjuvant treatment included chemotherapy and radiotherapy. There was a higher survival rate among patients undergoing adjuvant chemotherapy than those who underwent multimodal treatment (p-value=0.0001). There was no significant difference in survival between patients with endometrial cancer and those with sarcoma (p-value=0.089).

Conclusion: Corpus uteri cancer is common in postmenopausal and multiparous women presenting at advanced stages. Adjuvant therapy did not confer any additional survival benefit, particularly in patients who received multimodal treatment.   

Author Biographies

Dr. Faiza Nassir, Department of Reproductive Health,College of Health Sciences,Moi University School of Medicine, Eldoret, Kenya.

Obstetrician Gynecologist, Gynecological Oncologist, Program, Director ECSACOG Coast General Teaching and Referral Hospital.

Dr. Peter Itsura, Department of Reproductive Health, Moi University, Eldoret, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Senior Lecturer, Department of Reproductive Health, College of health sciences, Moi University School of medicine.

Dr. Benjamin Elly Odongo, Department of Reproductive Health, Kenyatta University, Nairobi, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Senior Lecturer Department of Reproductive Health, Kenyatta University

Prof. Elkanah Omenge Orang'o, Department of Obstetrics and Gynecology, Aga Khan University, Nairobi, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Dean Aga Khan University, Department of Obstetrics &amp; Gynecology.

Dr. Philliph K. Tonui, Department of Reproductive Health, Moi University, Eldoret, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Senior Lecturer Department of Reproductive Health, College of health sciences, Moi University school of medicine.

Dr. Henry Chege, Department of Obstetrics and Gynecology, Nyeri Teaching and Referral Hospital, Nyeri, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Nyeri Teaching &amp; referral Hospital

Dr. Anisa W.Mburu, Department of Obstetrics and Gynecology, Aga Khan Hospital, Mombasa, Kenya

Obstetrician Gynecologist Gynecological Oncologist, Aga khan Hospital Mombasa

Hellen N. Muliro, Academic Model Providing Access to Healthcare (AMPATH) Kenya - Moi University, Eldoret, Kenya

Research assistant- Academic Model Providing Access to Healthcare (AMPATH) Kenya - Moi University, Eldoret, Kenya.

Dr. Barry P. Rosen, Division of Gynecologic Oncology, University of Toronto, Sunnybrook Health Science Centre, Toronto, Canada

Obstetrician Gynecologist Gynecological Oncologist, Oakland University William Beaumont School of Medicine.

Dr. Allan L. Covens, Department of Gynecology Oncology, Beaumont Hospital, Royal Oak, Michigan, United States

Obstetrician Gynecologist Gynecological Oncologist, Department of Gynecology Oncology, Beaumont Hospital, Royal Oak, Michigan, United States.

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Published

2023-09-30

How to Cite

Nassir, F. ., Itsura, P., Odongo, B., Orango, E., Tonui, P., Chege, H., Mburu, A., Muliro, H., Rosen, B. ., & Covens, A. (2023). Treatment outcomes of corpus uteri cancer at Moi Teaching and Referral Hospital, Kenya: A 10-year retrospective study. Journal of Obstetrics and Gynaecology of Eastern and Central Africa, 35(3), 91–97. https://doi.org/10.59692/jogeca.v35i3.56

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